Oxytocin Improved Social Behaviors in Autism In a 16-year-old girl with autism, long-term administration of oxytocin via nasal spray dramatically reduced irritability and aggressive behavior and improved social interactions
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چکیده
The patient, who was high-functioning, presented for evaluation of incomprehension of others' mind, aggressive behavior including self-injury, and marked impairment in social interactions. Her score on the Aberrant Behavior Checklist (ABC), completed by her mother, was 69 (very high), with individual items indicating hyperirritability, aggression, bizarre behaviors, and poor empathy. She received a diagnosis of autism and underwent several months of treatment with behavioral therapy and psychoeducation, in addition to trials of risperidone and antianxiety agents. Her symptoms did not improve, and she experienced extrapyramidal symptoms and drowsiness associated with the medication.
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Long-term oxytocin administration improves social behaviors in a girl with autistic disorder
BACKGROUND Patients with autism spectrum disorders (ASDs) exhibit core autistic symptoms including social impairments from early childhood and mostly show secondary disabilities such as irritability and aggressive behavior based on core symptoms. However, there are still no radical treatments of social impairments in these patients. Oxytocin has been reported to play important roles in multiple...
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